ABSTRACT
Designer drugs are structural or functional analogs of controlled substances that have been created to mimic the effects of the classic drugs, while avoiding classification as illegal and detection in standard drug tests. Gas chromatography–mass spectrometry (GC-MS) was also applied for the discrimination and identification of the several aromatic positional isomers of trimethoxyamphetamine. The developed method allowed both mass spectrometric and chromatographic differentiation. The most popular technique used in forensic laboratories dealing with drug analysis is GC-MS. Liquid chromatography–mass spectrometry is a powerful analytical tool, which has a broad application in forensic toxicology and drug analysis. Isomerism is the phenomenon of existence of two or more compounds of the same molecular formula, but of a different structure. The use of multiple analytical procedures for the discrimination of designer drugs is essential and ensures the unequivocal identification of both constitutional isomers as well as stereoisomers.
