ABSTRACT
This chapter shows that the liquisolid technology can be used for the purpose of sustaining the release of highly water-soluble drugs if the suitable non-volatile solvent, carrier, coating and adjuvant materials are selected. Formulations prepared using liquisolid techniques are considered as free-flowing and compressible powders containing a nonvolatile liquid vehicle and solid drug particles. The excipient with very high surface area which usually covers the carrier surfaces containing liquid to improve flowability of liquisolid powders is known as coating materials. Carriers should be a porous material possessing high liquid absorption capacity. Coating material should cover the wet carrier particles adsorbing excess liquid to ensure good flowability. Liquid vehicle with less capability to dissolve the drug can be selected as a non-volatile solvent to obtain a better retardation effect. Differential scanning calorimetry is conducted to assess the thermal behaviors of the drug, excipients used in the formulation, as well as the liquisolid system prepared.
