ABSTRACT
The development of the reciprocating cylinder apparatus arose from
a need for an alternative drug release apparatus capable of providing
pharmacokinetic and mechanical conditions that more closely
represented the various regions throughout the gastrointestinal
tract. While the traditional paddle and basket apparatus offered a
convenient means to evaluate most oral drug formulations at single
andmultiple pHs and over long periods, it was difficult to change pH
during the test and changes in agitation rates during the in vitro test
are seldom noted as well.
