ABSTRACT
Adult stem cells are found in many tissues and organs such as
brain, blood, bone, skin, lung, and liver, where they stay in a special
structure called “stem cell niche.” They remain quiescent under
normal conditions and become activated when there is a need to
repair injury or maintain tissue. Stem cells are very promising in
regenerative medicine to treat injury and disease. However, when
isolated and cultured in vitro, stem cells have limited capacity to divide, which makes it difficult to grow large quantities of stem
cells for medical application. Low-level laser therapy (LLLT) has
been demonstrated to stimulate the proliferation of many kinds
of cultured cells, including stem cells. The augmentation of stem-
cell-based therapies to modulate regenerative process through LLLT
holds great potential. The mechanisms of action, the effects of LLLT
on stem cells, and the potential applications of LLLT on stem-cell-
based treatment are discussed in this chapter.
