ABSTRACT
Bone is a specialized connective tissue composed of 33% organic
matrix, comprising 28% of type I collagen and the rest of non-
collagenous proteins, including osteocalcin, osteonectin, BMPs,
sialoproteins, and bone proteoglycans, which are arranged to
form bones, rigid and resistant structures that form the skeleton.
Bone tissue is an adaptable structure, which develops according
to the types of mechanical forces received and their metabolic
needs. Bone metabolism also responds to hormonal regulation
and biomechanics, and these two regulatory mechanisms are
antagonists. Nowadays, a major problem in many specialties is the
process of repair of defects caused by trauma, surgical procedures,
or pathologic conditions.
