ABSTRACT
O. V. KARBAN,1 M. M. KANUNNIKOV,2 N. N. CHUCHKOVA,2 N. V. SAVINOVA,2 V. V. MUKHGALIN,1 F. Z. GILMUTDINOV,1 V. KOMISSAROV,2 and E. G. BUTOLIN2
1Physic-Technical Institute of the Ural Branch of the Russian Academy of Sciences (PhTI UB RAS), Izhevsk, Russia
2Izhevsk State Medical Academy, Izhevsk, Russia
3.1 Introduction .................................................................................... 42 3.2 Experimental Researches ............................................................... 43 3.3 Results and Discussion .................................................................. 45 3.3.1 Structure of Mechanoactivated Magnesium Orotate .......... 45 3.3.2 Chemical State of the Initial and Mechanoactivated
Magnesium Orotate ............................................................ 46 3.3.2.1 Physical and Chemical Properties ....................... 49 3.3.3 Biological Properties of the Initial
and Mechanotreatmented Magnerot ................................... 51 3.3.3.1 Biolelectric Activity of the Cells ......................... 51 3.3.4 Investigation on Hypomagnesaemia Model ....................... 52 3.3.5 Investigation on Steroid-Osteoporosis Model .................... 53
3.4 Conclusion ..................................................................................... 54 Acknowledgments ................................................................................... 55 Keywords ................................................................................................ 55 References ............................................................................................... 55
3.1 INTRODUCTION
Heart diseases are the first cause of death in most countries of the world. In the ex-USSR countries, this death rate is twice as high as in Europe. It evidences that the drugs intended to prevent and cure heart diseases are either inefficient or too expensive for most patients. The common approach to finding effective drugs is based on development of new chemical compounds showing improved properties. The whole cycle, including synthesis of the drug, study of the physical and chemical properties, bioactivity testing on animals, and clinical trials, takes over 10 years and costs approximately 1 billion USD. This approach needs much time and a lot of funds.
