ABSTRACT
The aim of our studies is the study of the adsorption of technetium99m alumina nano-sized structures for nano-colloid radiopharmaceutical preparation used in medical diagnosis of cancer.
8.2 EXPERIMENTAL RESEARCHES
The best method for identifying SLN is use labeled with technetium-99m colloidal nanomaterials for radiometric or scintigraphic localization of lymph node [6]. Wherein the determining factor in selecting of indicator is the size of radioactive particles. Thus, according to Schauer et al. [5], a colloid particle with size less than 50 nm can accumulate not only in SLN, but also in subsequent nodes. Particles greater than 100 nm slowly migrate from the injection site. Optimal for identifying SLN was recognized colloid particle size from 50 to 80 nm. To date, all known nanocolloid preparations are made on the basis of compounds that form stable hydrosols. At the same time as the starting compounds for their preparation are often chosen organic substances of different structures, the complexity of the synthesis of which largely determines the high cost of such products. Another part of the radiopharmaceutical preparation is inorganic 99mTc complexes with sulfides of rhenium and antimony, which are also obtained by sufficiently sophisticated technology that prevents their widespread use in practical medicine.
