ABSTRACT
The 1,3-dipolar cycloaddition is an elegant and atom-efficient process for the synthesis of spiro heterocycles, involving the formation of C–C and C–N bonds in a single step. The construction of a spiro heterocyclic framework has always been a challenging endeavor for synthetic organic chemists as it frequently requires synthetic design based on 1,3-dipolar cycloaddition reactions. This review gives a short summary of the advances for the selective synthesis of various spiro heterocyclic compounds through multicomponent reactions and 1,3-dipolar cycloaddition reactions with the main emphasis on the work done in our laboratory.
