ABSTRACT
β-Carboline-based alkaloids are widespread in nature, including plants and animals, possessing a broad spectrum of pharmacological properties showing antimicrobial, antitumor, anxiolytic, anti-HIV, antimalarial, sedative, hypnotic, anticonvulsant, etc. In this context, here, we have compiled the various methodologies that have been explored for the synthesis of 1-formyl-9H-β-carboline. Furthermore, various synthetic applications of this new synthon have been compiled in this chapter, which have been investigated for the generation of various substituted and fused-β-carboline derivatives. It is further envisaged that targeted exploration of rationally designed β-carboline derivatives could afford the new anti-infective drugs.
