Microsphere deposition, dosimetry, radiobiology at the cell-scale, and predicted hepatic toxicity

Over the past decade, it has become well established that hepatic toxicity per Gy is signicantly dierent between 50 Bq/sphere resin and 2500 Bq/sphere glass 90Y microspheres (Kennedy et al., 2007). An overview of the similarities and dierences between resin and glass microspheres is presented in Chapter 1. e hepatic toxicity per unit absorbed dose of glass microspheres is about onethird of that observed in external beam radiotherapy (EBRT) (Dawson et al., 2001).