ABSTRACT

Introduction .............................................................................................................................................374 Serotonin: A Predominant Wake-Promoting Neurotransmitter ..............................................................375 Serotonin: A Common Link between Depression and Sleep ..................................................................375 Serotonin Plays a Crucial Role in the Development of Respiratory Rhythm and Maintaining Airways during Sleep ............................................................................................................................. 376 Melatonin: Its Role in Normal Circadian Rhythm Sleep-Wake Cycles and in Circadian Rhythm Disorders ................................................................................................................................................ 377

Delayed Sleep Phase Syndrome (DSPD) .......................................................................................... 378 Advanced Sleep Phase Disorder (ASPD) ......................................................................................... 378 Jet Lag Disorders .............................................................................................................................. 378 Shift Work Disorder .......................................................................................................................... 378

Conclusion ............................................................................................................................................. 379 References .............................................................................................................................................. 379

KEY WORDS: serotonin, melatonin, circadian rhythm disorders, depression, sleep.