ABSTRACT
Abstract Recent advances in the understanding of structural MRI correlates of ASD reveal some patterns. Cross-sectional region-of-interest-based studies reported changes in total brain volume and the corpus callosum volume. Longitudinal region-of-interest-based studies reported subjects with ASD had atypical cortical thickness trajectories. Voxel-based morphometry-based studies reported increased gray matter volume and reduced gray matter density in the frontal and temporal lobes. Surfacebased morphometry-based studies reported that regions in the temporal lobe showed thinner cortex in the ASD group. For brain network analysis, structural covariance analysis-based studies found atypical anatomical connectivity patterns in ASD. For predictive modeling, structural MR-based predictive models can accurately differentiate individuals with ASD from normal controls.
