ABSTRACT
Abstract The corpus callosum (CC) is the largest white matter structure connecting the left and right hemispheres of the human brain. Many studies have revealed that the topology, integrity, and connectivity of the CC of individuals with autism spectrum disorder (ASD) are different from neurotypical controls. In addition to ASD, various neurogenetic syndromes exhibiting social interaction decits (e.g., neurobromatosis type 1) also manifest abnormalities of the CC. Although much evidence supports the association of CC abnormalities with the ASD phenotype, abnormal CC is still not a pathognomonic sign of ASD. Much research is needed to further our understanding of the role of CC in the pathophysiology of ASD.
