ABSTRACT
This chapter explores functional magnetic resonance imaging (fMRI) modality as an applicable tool for diagnosis and clinical research in humans. It presents fMRI applications and functional connectivity (FC) in different disciplines. The chapter reviews various studies being conducted using fMRI as a biomarker and presents findings on stroke rehabilitation. Therefore, the application of fMRI in the clinical setting is a different challenge, depicted in the study designs as well as in the analysis of neuroimaging data algorithms. MRI was a significant improvement over other available neuroimaging techniques. FC has been extensively evaluated with several functional neuroimaging methods, particularly fMRI. More specifically, in the analysis of neuroimaging, time-series FC is defined as the temporal correlations between spatially remote neurophysiological events. Overall, fMRI is the mainstay of neuroimaging in cognitive neuroscience. fMRI is a technique for measuring and mapping brain activity that is noninvasive and safe.
