ABSTRACT
INTRODUCTION Hormones play an important role in the life span of each individual. In particular, skin is recognized as a hormonedependent organ [1-3]. Metabolic effects related to the amounts of hormones reaching the skin and the intrinsic cutaneous neuroendocrine activity are important to consider. In addition, like any other organ, the hormonal system is inuenced by the global aging process. This leads to various deteriorations possibly responsible for functional deciencies. Such involution in turn inuences the multifaceted global aging machinery operative in the skin. Quite distinct are the skin manifestations of some endocrinopathies mimicking or interfering with skin aging [4,5]. Endocrine treatments and endocrine disruptors interfere with the natural endocrine status.
