ABSTRACT
INTRODUCTION The human aging process is complex. Platelet-rich plasma (PRP) can be used for skin regeneration and rejuvenation.
With the aging process, the epidermal layer changes less than the dermis where the number of cells and their reproductive activity slows down [1]. Consecutively, the levels of collagen, hyaluronic acid, and glycosaminoglycans decrease. Collagen accounts for as much as approximately 70% of the skin’s dry weight and plays a pivotal role in maintaining the skin’s structure. Collagen which exists in the following subtypes: Type I and Type III collagen are present in the highest amounts, Type IV collagen which is the main component of the lamina densa, Type VII collagen which is present at the dermal-epidermal interface, and Type V collagen which is found pericellularly [2].
