ABSTRACT
INTRODUCTION The most common malignancy of the central nervous system (CNS) is metastatic disease,10,36 which accounts for approximately 20 per cent of clinically significant brain neoplasms.25 CNS metastases affect more than 100 000 patients in the United States alone each year,23 with an annual incidence of at least 11 individuals per 100 000 in the population.36 Consequently, metastases are among the most common neuropathology specimens submitted to the anatomic pathology laboratory for the adult patient population.3
