This chapter discusses system evaluation aiming at identifying the interaction between system use and road safety. It aims to describe the evaluation procedure for assessing interaction between the system user and the system through the impact of system use on drivers-users and drivers’ tasks. The increase of safety in driving with system use can also result in a modification of driving exposure in specific situations. Questions eliciting participant opinions related to system use and operation, and their effect on driver behaviour are the most commonly used ones. Laboratory methods may be used in combination with other types of methods, involving driving experiments and require method specialised equipment. Driving scenario design involves the driving environment and prevailing conditions, and is more complicated in the driving simulator experiment in comparison to the instrumented vehicle experiment.