ABSTRACT
To obtain the developed force of a SMC, we used a modified Hai-Murphy model (from the original model of Hai-Murphy (Hai CM, 1988), originally developed for airway SMCs) which is adapted to the uterine muscle (Maggio CD, 2012). This model has been chosen because it is commonly used to determine the force generation of SMCs (Wang I, 2008; Hai CM, 2005; Yang J, 2003), and it has also been correlated with experimental measurements, particularly for the uterine muscle (Maggio CD, 2012; Bursztyn L, 2007) focus of this study. In this work, the Hai-Murphy model is coupled with an electrical model previously developed in our team (Laforet J, 2011) which includes the intracellular concentration of calcium ions. In this paper, we first introduce the electrical model of the uterine SMC and then the mechanical model.
