Osteonecrosis of jaw by bisphosphonates: About a case

Early diagnosis is essential for patients and clinicians, given the slight hope of restitution the original condition (Di Fede et al., 2013). Clinically, the most frequent sign is bone exposure even if different symptoms and minor signs (i.e. pain, hypoesthesia/paraesthesia, fistula, abscess, swelling, trismus) should raise suspicions of ONJ (Di Fede et al., 2013). Histologically, the necrotic bone is usually associated with contamination with actinomyces, showing no signs of malignancy (Carvalho et al., 2008; Van Poznak & Estilo, 2006).