ABSTRACT: The bio-psycho-social model of health provides a framework to assess and/or treat various medical disorders, but it not without its limitation. The model is particularly helpful in chronic conditions and has been identified as the most heuristic approach to managing chronic pain. Fibromyalgia (FM) is a chronic pain disorder primarily affecting women that is characterized by widespread musculo-skeletal pain, abnormal pain processing, sleep disturbance, fatigue, and often cognitive difficulties and psychological distress. Evidence-based management guidelines from various associations in different countries suggest bio-psycho-social intervention to include pharmacological therapy, exercise, cognitive-behavioral therapy, and multi-component intervention. State-of-the-art evaluation and treatment approaches in FM illustrate one application of the bio-psycho-social model to improve women’s health.