ABSTRACT
Nanomaterials in their direct/embedded form have become contributors toward enhancement in functionalities for a range of commodities. Keeping in mind the huge influx of nanoembedded products available in the market, it becomes imperative that we understand the true biological impact of nanomaterials. Nanosafety studies have mainly been conducted through nanotoxicological studies wherein the toxicological impact of nanomaterial was examined on a range of biological systems. Unlike other physicochemical properties of nanomaterials, which have been studied extensively as a contributing factor for toxicity, dissolution is rather complex because nanoparticle solubility can be looked upon as one of the physicochemical parameter standalones, or as a property that is affected by changing other physicochemical parameters (e.g., size, shape, surface chemistry, porosity crystallinity, etc.). Hence, in this chapter, a detailed discussion is given on the dissolution of nanoparticles, factors affecting dissolution, measurement of nanoparticle dissolution, and biological implications of dissolution for better understanding and design of safe nanoparticles.
