ABSTRACT
The opportunistic pathogen P. aeruginosa is responsible for severe acute infections in immunocompromised patients or in intensive care, as well as chronic pulmonary infections in patients with cystic fibrosis. It has several secretion systems, including a type III secretion system. P. aeruginosa has four types of effector proteins: ExoS, ExoT, ExoU, and ExoY. The opportunistic pathogen P. aeruginosa is responsible for severe acute infections in immunocompromised patients or in intensive care, as well as chronic pulmonary infections in patients with cystic fibrosis. Several studies reported that multiantigen immunization is more efficient than immunization by a vaccine with a single antigen because the latter pattern can prime diverse T lymphocyte responses and stimulate immunity to a broad array of antigens. Actually, this pattern has been applied in the design of cancer vaccines and its efficiencies have been validated not only in animal experiments but also in human trials.
