In the EU project Roll2Rail, a Universal Cost Model (UCM) is developed, where innovations in running gear can be analysed within a simplified Life Cycle Cost (LCC) framework regarding its impact on energy, noise, vehicle damage and track damage. In this paper, the developed methodology for wheel damage calculation will be described. Besides, it will demonstrate different study cases for a regional train and extrapolate the differential LCC of different infrastructure parameters and vehicle technologies. Both the results and the implementation of the damage calculation methods are discussed, and the benefits of a unified methodology for a wide range of stakeholders are presented.