ABSTRACT
Monoclonal antibody technology provides a specific means of determining antigenic expression. This chapter shows that an antigenic profile in the cotton-top tamarins (Saguinus Oedipus) may differ from the human, depending upon the method of detection. Tumor markers for the detection of gastrointestinal cancer and as adjunct to therapy have been described but they are far from ideal. Some of tumor markers have been evaluated in the setting of human inflammatory bowel disease. Of the many challenges facing Western medicine, few are more urgent than the need to reduce the mortality from colorectal cancer (CRC) and more confounding than the elucidation of the pathogenesis of idiopathic colitis.post-mortem specimens taken from 15 animals dying of colitis, CRC, or unrelated disorders were formalin-fixed and full-thickness colonic 4-µm sections were cut from the paraffin blocks for immunohistochemistry. Approximately one third of the animals examined died as a direct result of CRC, consistent with the reported prevalence.
