ABSTRACT
This chapter reviews the adverse effects of antihistaminic agents in light of reports associated with dermal exposure. It includes all the therapeutic uses for which antihistaminic drugs are prescribed in adults. The histamine-induced vasoconstriction in the vasculature is completely blocked, while the vasodilation component is only partially affected by antihistaminics. The H1 blockers also exert pharmacological actions unrelated to the H1 receptor. It should also be mentioned that H1 antagonists are utilized by themselves in certain conditions such as allergic skin diseases. When used properly, antihistamines play an important role in the therapy of allergic disorders in children. An important feature associated with severe antihistamine intoxication and death is the route of administration. Antihistamines administered alone or in combination with other agents have been promoted as effective agents in combating symptoms associated with the common cold. The management and treatment of antihistamine intoxication is symptomatic and supportive.
