ABSTRACT
The furosemide-induced inhibition of proximal tubule sodium reabsorption is of short duration and accounts for the observed pharmacological peak. In contrast, indomethacin was reported to block the pharmacologic and toxicologic effects of furosemide. Data clearly show that furosemide is an effective, potent diuretic in fluid overload conditions associated with congestive heart failure and pulmonary edema. In pediatrics, diuretics are utilized to mobilize edema fluid, thereby resulting in the production of a negative fluid balance and a return of extracellular fluid volume to a normal state. Pulmonary edema has also been implicated in the disease transient tachypnea of the newborn. Clearly, there are a number of neonatal diseases associated with fluid imbalance which provide a basis for the therapeutic use of diuretics. Furosemide was found to produce a significant diuresis and saliuresis in infants with fluid overload associated with congenital heart disease as well as in edematous states due to other causes.
