ABSTRACT
This chapter provides short notes on the recovery of dietary fat-soluble xenobiotics from animal tissues and in vitro preparations. The fat-soluble xenobiotics may be defined as both noxious and relatively harmless substances derived from natural and synthetic sources. The great variety of chemical structures and wide range of their molecular weights allow an assessment of the critical factors of micellarization and membrane uptake, which is not possible with the more limited forms of the dietary lipids. Fat-soluble organic pesticides, such as dichlorodiphenyl trichloroethane and dichlorodiphenyl dichloroethylene, are found in small quantities in body fat of normal human subjects following their use for agricultural and farm purposes. The intestinal absorption of the neutral hydrocarbons has challenged the imagination of lipid physiologists and biochemists for many decades and has served as proof of either absorbability or nonabsorbability of given lipid forms. The absorption of polycyclic hydrocarbons in experimental animals has been studied extensively.
