ABSTRACT
The antibody inhibited chromosome replication by only 30% while DNA polymerase a antibodies produced a 73% inhibition of replication. These studies supported the notion that cyclin proliferating cell nuclear antigen (PCNA) is involved in DNA replication in living cells and further underlined a role for DNA polymerase d in this process. The antibody inhibited chromosome replication by only 30% while DNA polymerase a antibodies produced a 73% inhibition of replication. The first evidence suggesting that cyclin (PCNA) may play a role in DNA replication came from studies of Celis and Celis which showed that immunofluorescence patterns of cyclin antigen distribution mimicked topographical patterns of DNA replication.
