ABSTRACT

Liposomes give a unique opportunity to introduce drugs inside the cell with which they are thought to interact by fusion or endocytosis, or even inside the lysosomes. Thus, it is no wonder that biomedical aspects of liposome use, mechanisms of their interaction with cells, ways of effective loading of liposomes with drug preparations, liposome pharmacokinetic properties have been studied in detail or is under investigation. Evidently, to obtain the “targeted” liposomes it is necessary to develop methods of binding of corresponding vectors to the outer surface of liposomes. The method of electrostatically concentrating the appropriate protein near the surface of liposome, worked out while studying the adsorption method, is most interesting. Co-immobilized sialogly coprotein, without affecting the targeting capacity of the immobilized immunoglobulin re moves its undesirable side effect. The problem of macromolecule, primarily of protein, binding to the liposome surface is of particular concern also because of other reasons.