ABSTRACT
Neuroparacoccidioidomycosis (NPC) may occur without any other manifestation of the disease and there may be histopathologically-proven NPC in patients with no clinical symptoms. The diagnostic advances brought by computerized tomography (CT) and magnetic resonance (MR) have opened new avenues for the noninvasive diagnosis of central nervous system disease, including this mycosis. The analysis of the available data shows an increasing number of reports on NPC, most of which correspond to neurosurgical or to anatomopathological findings. C. A. Dominguez reinforced the assumption that NPC was not a rare entity and described additional anatomopathological features such as vascular changes which may increase the damage caused by the disease itself. In NPC, the parenchymatous form is the most common manifestation. Both the meningitic and the parenchymatous form of NPC are treated with antifungal drugs; surgical treatment is restricted to specific cases.
