ABSTRACT
Renal transplantation in patients with Antiphospholipid Syndrome (APS) justifies sustained anticoagulation to prevent graft thrombosis. Renal manifestations such as systemic hypertension and/or moderate renal failure are frequently encountered in Sneddon's syndrome, clinically defined as the association of livedo with ischemic strokes. Renal vein thrombosis is a frequent complication of the nephrotic syndrome, regardless of its etiology. Isolated observations of severe or malignant hypertension occurring during systemic lupus erythematosus in the absence of proliferative nephritis have been reported, for which the responsibility of vascular lesions was preferred because of the presence of antiphospholipid antibodies. Anticardiolipin antibodies appear more common when the initial nephropathy is glomerulonephritis. Antiphospholipid antibody-related intrarenal thromboses can be responsible for diverse clinical pictures. In 1989, Dieter Kleinknecht et al. reported cases occurring in the course of APS, including one with thrombotic microangiopathy and one with severe cortical ischemia.
