ABSTRACT
The Antiphospholipid antibodies (aPL) can be found as deposits in organs afflicted with Antiphospholipid Syndrome (APS). A typical APS was induced in mice, using either passive transfer or active immunization with aPL, indicating that the aPL are not only an epiphenomenon, but are themselves pathogenic. A. Kornberg et al. suggested that the tissue factor-like activity induced by anticardiolipin antibodies (aCL) in monocytes may activate coagulation and thereby play a major role in the pathogenesis of thromboses formation in APS. Increasing interest in APS prompted E. N. Harris et al. in 1983 to develop a solid phase radioimmunoassay and later on enzyme-linked immunosorbent assay, using cardiolipin as the antigen. R. Shurtz-Swirski et al. showed that several mouse monoclonal antibodies caused an increase in the pulsatility of eight human choriogonadotropins, while human polyclonal aCL, derived from patients with the APS, had an inhibitory effect.
