ABSTRACT
This chapter aims to review the antitumor activity of various chemical structures recognized as investigational anticancer drugs, which have shown antitumor activity in human tumor xenograft systems, and reach, in the light of this review, some conclusions which hopefully improve the selection of true positive anticancer drugs. It reviews the chemotherapeutic effects of some investigational drugs against human tumor xenografts. The activity of diaziquone (AZQ) against a series of human brain tumor lines grown in nude mice has also been investigated. Prostaglandin A (PGA) inhibits the growth of rodent and human tumor cells in vitro. This observation led to the investigation of Prostaglandin A (PGA) in the possible inhibition of the growth of human melanoma xenografts. Alkyl lysophospholipids are synthetic analogs of the naturally occurring 2-lysophosphati-dylcholine and represent a new class of antimetabolite antitumor agents.
