ABSTRACT
Total parenteral nutrition (TPN) admixtures are very complex multicomponent solutions with great potential for physicochemical interactions that may be extremely difficult to analyze. There is relatively little information available on the stability and compatibility of TPN admixtures. Aqueous solutions of single-entity and multiple-component trace elements manufactured by individual hospitals are quite stable, and today similar commercial products are available. Solutions of the halogen salts are recommended for optimum stability particularly in preparations containing multiple components. The physical and chemical stability of vitamins in parenteral nutrition solutions is subject to much debate at present. Trials have shown that multivitamin preparations are physically compatible with various commonly used intravenous infusion fluids, including protein hydrolysates and dextrose. Microbiological growth is a major complication with TPN admixtures. Although these solutions are prepared under controlled aseptic conditions Candida septicemia does occur from time to time.
