This chapter presents the theoretical perspective grounded in the Industrial Marketing and Purchasing (IMP) approach and the Actors, Resources. Activities (ARA) model. It outlines the research setting and the case study, which is then followed by the objectives of the research methodology, and framework for data analysis. The chapter also presents the results and a discussion of the major findings. It reports concluding remarks indicating that the heterogeneity of the actors’ operating in innovative health care construction projects works both as a facilitator and as a developer of friction in the renewal processes. Health care is one of the areas where the rate of progress of science and technology has been most remarkable, both in terms of medical procedures and technologies and innovations in the construction dynamics and solutions developed. The interrelations among the local and global actors generated a cross-fertilization among construction and related clinical actors, pushing them towards interdependencies and also interplay, ultimately affecting how innovation manifested.