ABSTRACT
As Giardia genomes harbor ~5,000 protein-coding genes, of which up to 50% have unknown functions, proteomic analysis offers a valuable tool for the characterization of Giardia proteins and contributes toward the full elucidation of Giardia pathogenesis. By proteomic analysis of a mitosome-rich cellular fraction and immunofluorescence microscopy, Rada et al. identified a novel mitosomal protein homologous to monothiol glutaredoxins containing a CGFS motif at the active site, adding new components to the mitosomal FeS cluster biosynthetic pathway. Apart from timely detection and tracking of Giardia outbreaks and implementation of appropriate treatment and prevention measures, a detailed understanding of molecular mechanisms of Giardia infection is crucial for the development of intervention strategies for its ultimate elimination. Prevention of Giardia infection involves avoiding ingestion of contaminated water and food, provision of sewage treatment facility, and education.
