ABSTRACT
Abstract ................................................................................................... 46 2.1 Introduction .................................................................................... 46 2.2 NPs and Nanovesicles Based on Surfactants ................................. 48 2.3 Role of Surfactants in the Delivery of Drugs by Different Routes ...54 2.4 Role of Surfactants on the Efficacy of Cancer Chemotherapy ...... 61 2.5 Conclusion ..................................................................................... 63 Keywords ................................................................................................ 64 References ............................................................................................... 64
M. PILAR VINARDELL1*, DANIELE R. NOGUEIRA-LIBRELOTTO2,3, CLARICE M. B. ROLIM2,3, and MONTSERRAT MITJANS1
1Department Bioquimica i Fisiologia, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Av. Joan XIII, 27-31, Barcelona 08028, Spain 2Department Farmácia Industrial, Universidade Federal de Santa Maria, Av. Roraima 1000, 97105-900 Santa Maria, Rio Grande do Sul, Brazil 3Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima 1000, 97105-900 Santa Maria, Rio Grande do Sul, Brazil
*Corresponding author. E-mail: mpvinardellmh@ub.edu
ABSTRACT
The delivery of drugs using nanocarriers has several advantages, such as protection from degradation, enhanced solubility and stability, increased surface area, and controlled and/or triggered drug release. To stabilize emulsions and reduce particle aggregation during particle synthesis, storage, and use, the surfaces of drug-loaded polymeric particles are usually coated with surfactants. Surfactants can influence particle size, morphology, encapsulation efficiency, and drug release kinetics. Different kinds of surfactants are used in these formulations, depending on their properties.
