ABSTRACT
This chapter focuses on imaging genomics applications beyond oncology, specifically in the study of brain disorders. Brain imaging genomics investigates the influence of genetic variation on neuroimaging phenotypes. Recent technological advances in acquiring high-throughput genomic data and multimodal imaging data have greatly facilitated the investigation of brain imaging genomics, which has the potential to improve the understanding of molecular mechanisms underlying normal or disordered brain structure and function. In this chapter, we aim to provide an introduction to this emerging research field, from the principles and methodologies to detailed applications and discoveries. In particular, we first provide a systematic review on the strategies applied in this field. After that, we summarize the research progress of imaging genomics studies and findings on several common brain diseases including neurological and psychiatric disorders. Finally, we provide a discussion on the strength and limitation of brain imaging genomics in comparison with imaging genomics in oncology.
