ABSTRACT
Breast cancer is the most prevalent cancer in women worldwide, and the second-most common cause of cancer death in many countries, including the United State. Mammography has been found to be effective in reducing breast cancer mortality by a number of cohort and case-control studies although the cost of over-diagnosis has been a topic of controversy and study in recent years. Digital breast tomosynthesis (DBT) is a new imaging modality that has been introduced into clinical use in the past few years. Detection of microcalcifications in DBT is especially important if DBT would replace DM for screening because no other imaging modalities can detect calcification as effectively as DM and calcification is an important sign of early stage breast cancer. Computer-aided detection (CAD), therefore, is expected to play a similarly important, if not more important, role for DBT as for DM in clinical practice.
