Agronomic biofortification through fertilization helps to increase plant nutrient content without changing the plant's genetic makeup. Application of microelement fertilizers in the form of inorganic salts is the most common procedure within the agronomic biofortification practice. Organic fertilizers perform soil-conditioning functions. The addition of organic matter improves the physical, chemical, and biological properties of soils. It is well documented that microelements supplemented in the form of chelates result in good bioavailability. Foliar application has been found to be the most promising fertilization method for increasing zinc content in edible parts of plants. Crops may be fertilized with micronutrients through seed treatments, which refer to the application of one or more elements to seeds. A fertilizer strategy represents a rapid and effective way for biofortification of food crops. However, other agricultural practices, such as application of macronutrients, crop rotation, intercropping, tillage, and water management, may also influence micronutrient content in crops.