ABSTRACT
The BIAcore technology, based on the surface plasmon resonance (SPR) phenomenon, is performed since more than 3 decades using biosensors which allow determining the capacity of molecules with high molecular weight as proteins to interact specifically with relative smaller molecules as DNA fragments, RNA, peptides, oligosaccharides, terpenes and phenolics. Furthermore, this technology can be also used for detecting microorganisms through specific interactions with sugars or amino acids residues. In all cases, we can know which molecules interact specifically with other ones at high sensitivity, but also get new information on their putative functions. So this technology offers large spectra of applications including food traceability that are presented in this chapter. An insight of the high potential of such technology is given, knowing that mass spectrometry analyses can be coupled with SPR technology using a microfluidic system. These potentialities will be discussed through very recent and informative data recently obtained by international scientific groups.
