An organization setting up or developing a project management office (PMO) must necessarily consider a range of dimensions and responsibilities such as those discussed in this chapter. In many cases, organizations unsystematically grapple with the design process. This chapter proposes that a group setting up a PMO can shortcut the process of designing a PMO, that will match the requirements and priorities of their organizations, by systematically evaluating the dimensions listed herein and adopting the design options that best meet their needs.