ABSTRACT
Bt = (Bo -nsb)*exp(-kc.rr*t) + nsb where B0 and B1 refer to observed binding at times 0 and t, respectively.
6. Interpretation These equations are empirical models to describe the data. If the data fit the simple model well without the need for an asymptote parameter, then the results are consistent with the mechanistic Law of Mass Action. The time for half the bound and displaceable radioligand to dissociate, t112 , is given by -ln(0.5)/kotf·
B. Association Analysis 1. Objective The objective of association analysis is to measure the rate and pattern of radioligand association.
