ABSTRACT
Figure 4 Photomicrographs of peripheral lung from a child who died of acute RSV bronchiolitis, stained with anti-RSV antibody. Note the positive cytoplasmic immunostaining of sloughed cells within the alveolar lumen (A, arrows) and intact alveolar epithethial lining cells (B, arrowheads). (Courtesy of Dr. James Dimmick, British Columbia's Children's Hospital of British Columbia, Vancouver, British Columbia, Canada.)
inflammatory mediators such as tumor necrosis factor (TNF), various interleukins, colony-stimulating factors, oxygen free radicals, interferons, prostaglandins, and platelet-activating factor. These potent molecules influence airway caliber by acting directly on smooth muscle and by modulating the exudative and cellular components of the inflammatory process. Further information about the effects of respiratory viruses on alveolar macrophage function is available in a recent review article by Lantz et al. (20).
