ABSTRACT
Kaufmann and Armant, 1992: Kholkute et al., 1994a,b) have provided evidence that toxic insult during the preimplantation period can have a deleterious effect on the normal development of the embryo leading to fetal, neonatal death. dysmorphogenesis. or indeed poor outcomes after birth. The toxic effects of alkylnitrosoureas on pregnant rodents have also been demonstrated to lead to failure to implant, embryonic death, and decreased binh rate (Napalkov et al., 1968).
