ABSTRACT
Freeze-drying (also known as lyophilization) has been a standard practice employed to manufacture many pharmaceutical products. The overwhelming majority of these products are lyophilized from simple aqueous solutions. Typically, water is the only solvent that must be removed from the solution via the freeze-drying process. However, there are still many instances where pharmaceutical products are manufactured via a process that requires freeze-drying from organic cosolvent systems (1).
