ABSTRACT
Sirtuins have an essential role in modulating histone H4 acetylation, are sensors of the metabolic environment, and, in higher organisms, have diversified to target nonhistone proteins. Sirtuins exhibit a very diverse pattern of localization that includes the nucleus, the cytoplasm, mitochondria, and the nucleolus. The Sir2 mechanism of action allows for an alternative activity, a mono-ADP ribosyltransferase that all sirtuins seem to exhibit and is key for the function of some. The Sir2 mechanism of action allows for an alternative activity, a mono-ADP ribosyltransferase that all sirtuins seem to exhibit and is key for the function of some. Among the Plasmodium species, Plasmodium falciparum causes the deadliest form of the disease. Trypanosomes are unicellular flagellated parasites responsible for several human diseases such as sleeping sickness, Chagas’ disease, and leishmaniasis. Aging is associated with a group of degenerative diseases and with cancer.
