ABSTRACT
Nanometrology is the science of measurements at the nanoscale, and its application underlies all the nanoscience and nanotechnology. There are several good reports and reviews which cover the production and characterization of nanoparticulates and nanoparticulate drug-delivery systems (NPDDSs). NPDDSs were primarily developed to combine the colloidal stability of solid particle suspensions in biological fluids and the solubilizing properties of liquids. An ideal drug-delivery system possesses two elements: the ability to target and to control the drug release. Colloidal drug carriers offer a number of potential advantages as delivery systems, such as better bioavailability for poorly soluble drugs. Compared with other colloidal carrier systems such as liposomes, albumin nanospheres have better stability, shelf life, controllable drug-release properties, and higher loading properties for hydrophilic molecules due to drug-binding properties of native albumin. An interesting novel drug-delivery system for improved all-trans retinoic acid therapy for external treatments of photo-damaged skin was developed.
