ABSTRACT
Nanoparticulate drug-delivery systems (NPDDSs) are being explored for the purpose of solving the challenges of drug delivery. NPDDSs have been utilized for their therapeutic applications over a wide range, from cancer treatments to some over the counter preparations. NPDDSs are designed to provide the drug release over an extended period of time, thereby minimizing the need for frequent injections. These can be used for systemic or oral delivery, and the biodegradable nature of the nanoparticulate materials alleviates the need for surgical removal. Nanoprecipitation techniques using poly lactic-co-glycolic acid and poly(lactic acid) polymers were found to be useful for nanoparticulate delivery of proteins and have shown more versatility and flexibility in the formulation for protein delivery. Intracellular gene delivery involves changing the expression of genes in order to prevent, cure, or treat a disorder or a disease. Effective delivery of genes into cells has been considered a major hurdle in achieving successful gene therapy.
